Protein Details: voltage-gated potassium channel AKT1

Protein ID

ICDB_Pro_0801

Protein Name

voltage-gated potassium channel AKT1

Gene Name

AKT1; Os01g0648000; LOC_Os01g45990

Organism

Oryza sativa subsp. japonica (Rice)

Length

935 amino acids

AlphaFoldDB

AF-Q0JKV1-F1-model_v4.pdb

Function

Highly selective inward-rectifying potassium channel that mediates potassium uptake by plant roots. Assuming opened or closed conformations in response to the voltage difference across the membrane; the channel is activated by hyperpolarization. May be a major salt-sensitive potassium channel in roots

Sequence

MARWGAARMAACGPWGRNRRVGAGDAFEASEVRRDGRSRMMPACGPWGAGHGGGDPALERELSRDGSHYSISSAILPSLGARSNRRIKLRRFIISPYDRRYRIWETFLIVLVVYSAWVSPFEFGFIPKPTGALATADNVVNAFFAVDIILTFFVAYLDKMSYMLEDDPKKIAWRYSTTWLVLDVASTIPSEFARRILPSKLRSYGFFNMLRLWRLRRVSSLFSRLEKDRHFNYFWVRCAKLICVTLFAVHCAACFYYLLADRYPVPTSTWIGNYMADFHERSLWIRYVTSVYWSITTLTTVGYGDLHAENTREMIFNIFYMLFNLGLTAYLIGNMTNLVVHGTSRTRNYRDTIQAATSFGVRNQLPPRLQDQMISHISLKYRTDSEGLQQQEILDSLPKAIKSSISQYLFFHLVQNVYLFQGVSNDLIFQLVSEMKAEYFPPREDVILQNEAPTDFYILVSGSVELVEQQNGADQVIQVATSGEVVGEIGVLCYRPQLFTVRTRSLCQLLRLNRTAFLSIVQSNVGDGTIIMNNLIQFLKEQKENSVMAGVVKEIESMLARGNLDLPITLCFAVTRGDDFLLHQLLKRGMDPNESDNDGHTALHIAASKGNEQCVRLLLEYGADPNARDSEGKVPLWEALCEKHAAVVQLLVEGGADLSSGDTGLYACIAVEESDTELLNDIIHYGGDVNRARRDGTTALHRAVCDGNVQMAELLLEHGADIDKQDGNGWTPRALAEQQGHDDIQLLFRSRKAATASGHHHVPSSTTTRVAPAAAAASLIGRFNSEPMMKNMIHEDADLPSRVLPEKLRRKRVTFQNSLFGVISSSQAQRETDHPLSRGGLAATGSPNPSSGSRNAVIRVTISCPEKGNTAGKLVLLPQTLDMLLELGAKKFDFAPTKVLTVEGAEVDEVELIRDGDHLVLVSNEWDAEKMKGKS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

419..538

Disease

Location

Expressed in roots and coleoptile of young seedlings.

DOI ID

10.1038/nature03895; 10.1093/nar/gkm978; 10.1186/1939-8433-6-4; 10.1126/science.1081288; 10.1007/s00425-004-1437-9

RefSeq

XP_015621694.1